Ну например, отлавливай таймером окно с заголовком "internet explorer" и закрывай его. Найти окно тебе поможет FindWindow,а закрыть окно - SendMessage.

Посмотри по сайту - примеров масса.

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Прошлый раз я немного не так посоветовал...
Когда ты FindWindow_ом будешь искать окно Explorera, окно его будет обзываться "Васи Пупкина страничка - Microsoft Internet Explorer"
Соответственно нужна функция находящая манипулятор окна по ЧАСТИ заголовка. Короче на тебе код. На форму 1 буттон (Command1) и весь код в форму. Нажмёшь на буттон, в инпут-боксе напишешь ЧАСТЬ заголовка нужного окна (напр: Internet Explorer или Explorer) и будет тебе великое сччастье...      

Option Explicit
Private Const WM_CLOSE = &H10
Private Const GW_HWNDFIRST = 0
Private Const GW_HWNDNEXT = 2
Private Declare Function PostMessage Lib "user32" Alias "PostMessageA" (ByVal hWnd As Long, ByVal wMsg As Long, ByVal wParam As Long, lParam As Any) As Long
Private Declare Function GetWindowTextLength Lib "user32" Alias "GetWindowTextLengthA" (ByVal hWnd As Long) As Long
Private Declare Function GetWindow Lib "user32" (ByVal hWnd As Long, ByVal wCmd As Long) As Long
Private Declare Function GetParent Lib "user32" (ByVal hWnd As Long) As Long
Private Declare Function GetWindowText Lib "user32" Alias "GetWindowTextA" (ByVal hWnd As Long, ByVal lpString As String, ByVal cch As Long) As Long

Private Function MyFindWindow(hWnd As Long, strCaption As String) As Long
Dim CurrWnd As Long, Length As Long, TaskName As String, parent As Long
CurrWnd = GetWindow(hWnd, GW_HWNDFIRST)
While CurrWnd <> 0
  parent = GetParent(CurrWnd)
  Length = GetWindowTextLength(CurrWnd)
  TaskName = Space$(Length + 1)
  Length = GetWindowText(CurrWnd, TaskName, Length + 1)
  TaskName = Left$(TaskName, Len(TaskName) - 1)
  If Length > 0 Then
    TaskName = LCase(TaskName)
    strCaption = LCase(strCaption)
      If InStr(1, TaskName, strCaption) > 0 Then MyFindWindow = CurrWnd
  End If
  CurrWnd = GetWindow(CurrWnd, GW_HWNDNEXT)
  DoEvents
Wend
End Function

Private Sub Command1_Click()
Dim sTmp As String, hW As Long, res As Long
sTmp = InputBox("строка присутствующая в заголовке")
If Len(sTmp) <= 0 Then Exit Sub '
hW = MyFindWindow(hWnd, sTmp)
PostMessage hW, WM_CLOSE, 0, 0
End Sub

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Немного непонятно, но всё-же... Может это:

Private Const MAX_PATH = 260
Private Declare Function ProcessFirst Lib "kernel32" _
Alias "Process32First" (ByVal hSnapshot As Long, uProcess _
As PROCESSENTRY32) As Long
Private Declare Function ProcessNext Lib "kernel32" _
Alias "Process32Next" (ByVal hSnapshot As Long, uProcess As _
PROCESSENTRY32) As Long
Private Declare Function CreateToolhelpSnapshot Lib "kernel32" _
Alias "CreateToolhelp32Snapshot" (ByVal lFlags As Long, _
lProcessID As Long) As Long
Private Declare Function CloseHandle Lib "kernel32" (ByVal hObject _
As Long) As Long
Private Declare Function OpenProcess Lib "kernel32" (ByVal _
dwDesiredAccess As Long, ByVal bInheritHandle As Long, _
ByVal dwProcessId As Long) As Long
Private Declare Function TerminateProcess Lib "kernel32" _
(ByVal hProcess As Long, ByVal uExitCode As Long) As Long
Private Type PROCESSENTRY32
    dwSize As Long
    cntUsage As Long
    th32ProcessID As Long
    th32DefaultHeapID As Long
    th32ModuleID As Long
    cntThreads As Long
    th32ParentProcessID As Long
    pcPriClassBase As Long
    dwFlags As Long
    szexeFile As String * MAX_PATH
End Type

Private Function KillApp(myName As String) As Boolean
    Const PROCESS_ALL_ACCESS = 0
    Dim uProcess As PROCESSENTRY32
    Dim rProcessFound As Long
    Dim hSnapshot As Long
    Dim szExename As String
    Dim exitCode As Long
    Dim myProcess As Long
    Dim AppKill As Boolean
    Dim appCount As Integer
    Dim i As Integer
    On Local Error GoTo Finish
    appCount = 0

    Const TH32CS_SNAPPROCESS As Long = 2&

    uProcess.dwSize = Len(uProcess)
    hSnapshot = CreateToolhelpSnapshot(TH32CS_SNAPPROCESS, 0&
    rProcessFound = ProcessFirst(hSnapshot, uProcess)

    Do While rProcessFound
        i = InStr(1, uProcess.szexeFile, Chr(0))
        szExename = LCase$(Left$(uProcess.szexeFile, i - 1))
        If Right$(szExename, Len(myName)) = LCase$(myName) Then
            KillApp = True
            appCount = appCount + 1
            myProcess = OpenProcess(PROCESS_ALL_ACCESS, False, uProcess.th32ProcessID)
            AppKill = TerminateProcess(myProcess, exitCode)
            Call CloseHandle(myProcess)
        End If
        rProcessFound = ProcessNext(hSnapshot, uProcess)
    Loop
    Call CloseHandle(hSnapshot)
Finish:
End Function

Private Sub Command1_Click()
Call KillApp("C:\Windows\Explorer.exe")
End Sub

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Попробуй выгружать процесс функцией TerminateProcess.

Но есть одна трабла с 2k/XP - ты его выгружешь, а винда опять запускает. Ну а если матсдай у тебя стоит, то проблем с выгрузкой нет. Если, есть вопросы намылишь - вышлю пример.

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Спасибо всем! Попробую!

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